Peptidoglycan and Fosfomycin

Most fun paper I've read yet! Sorry I can't put the pdf on here. I haven't figured that out yet.


Structure of UDP-N-acetylglucosamine enolpyruvyl transferase, 

an enzyme essential for the synthesis of bacterial 

peptidoglycan, complexed with substrate UDP-N- 

acetylglucosamine and the drug fosfomycin 

Tadeusz Skarzynski*, Anil Mistry†, Alan Wonacott, Susan E Hutchinson, 

Valerie A Kelly and Kenneth Duncan 

Structure15 December 1996, 4:1465–1474

Knock knock

Have you ever thought about life without a method to knock on doors? If knuckles weren't so painless and universal and effective, how would we know when our dear friends are at our doorstep or we on theirs? Here's to knocking on doors. So convenient.

Unless the Lord builds the house, those who build it labor in vain.  Unless the Lord watches over the city, the watchman stays awake in vain. Psalm 127:1

We put the fun in fungus

Tonight, this is entertainment side of my homework. It's pretty neat.

N. crassa ascospores

Of course, I don't know that I'm interested in fungus long-term, but I have an incredible opportunity to learn an incredible amount about single-gene deletion, genomic defense, gene regulation, and gene expression in eukaryotes. I absolutely love this class. We gather round a dark wood conference table to drink coffee, ask questions with an experienced and engaged Ph.D., and hypothesize about the functional genomics of fungus.

News to you, ya?

Antarctica penguins have suction cups on their feet and this is what keeps them from falling off the earth.

What else would it be? Gravity?

South pole penguin problems.

George Müller on seeking God's will, paraphrased

1. Seek at the beginning to get your heart into such a state that it has no will of its own in regard to a given matter.

2.  Having done this, do not leave the result to feeling or simple impression. (This leads to great delusions).

3.  Seek the Will of the Spirit of God through, or in connection with, the Word of God. The Spirit and the Word must be combined.  If you look to the Spirit alone without the Word, you lay yourself open to great delusions.  If the Holy Ghost guides us at all, He will do it according to the Scriptures and never contrary to them.

4.  Take into account providential circumstances.  These often plainly indicate God's will in connection with His Word and Spirit.

5.  Ask God in prayer to reveal His will to you aright.

6.  Thus, through prayer to God, the Study of the Word, and reflection, you come to a deliberate judgment according to the best of your ability and knowledge, and if your mind is thus at peace, and continues so after two or there more petitions, proceed accordingly.

The following things lead to mistakes:
Lacking honesty of heart
Lacking uprightness before God
Impatience to wait for God
Preferring the counsel of men over the declarations of Scripture

Too Soon?

Soundtrack of the day:

It isn't entirely too soon. What do you think Hailie? Is it ever too soon?

It you think it is too soon, be encouraged that this is a one-day Christmas music fix. Not to return until November.

November comes next week!

The hydrogen atom....

In P-chem we just finished a unit on the hydrogen atom and the shrodinger equation.  It is the mathematics of atomic electrons- their location, momentum, and energy.

I learned that the hydrogen atoms' electrons have no angular momentum!! Do you know what this means? This means that the electron does not move in a circle, like previously supposed by Bohr.

LIES

Instead, the electron moves towards the nucleus, and then away from the nucleus over and over again. In and out. In and out. Without going sideways at all.

It has a pathlength that looks more like this:

Take that sixth-grade science. 

AND, the lack-of-angular-momentum applies to the lowest energy orbital of every atom.  How cool.

By this all men will know that you are my disciples, if you have love for one another.    John 13:35